he Spore Coat Protein CotE Facilitates Host Colonization by Clostridium di cile
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The Spore Coat Protein CotE Facilitates Host Colonization by Clostridium difficile
Clostridium difficile infection (CDI) is an important hospital-acquired infection resulting from the germination of spores in the intestine as a consequence of antibiotic-mediated dysbiosis of the gut microbiota. Key to this is CotE, a protein displayed on the spore surface and carrying 2 functional elements, an N-terminal peroxiredoxin and a C-terminal chitinase domain. Using isogenic mutants,...
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Bacillus spp. and Clostridium spp. form a specialized cell type, called a spore, during a multistep differentiation process that is initiated in response to starvation. Spores are protected by a morphologically complex protein coat. The Bacillus anthracis coat is of particular interest because the spore is the infective particle of anthrax. We determined the roles of several B. anthracis orthol...
متن کاملCotE binds to CotC and CotU and mediates their interaction during spore coat formation in Bacillus subtilis.
CotE is a morphogenic protein that controls the assembly of the coat, the proteinaceous structure that surrounds and protects the spore of Bacillus subtilis. CotE has long been thought to interact with several outer coat components, but such interactions were hypothesized from genetic experiment results and have never been directly demonstrated. To study the interaction of CotE with other coat ...
متن کاملProteomic characterization of spore coat protein mutants of Bacillus subtilis
Spore coat proteins play an important role in maintaining spore structure as well as the resistive capacity of the spores. Spore morphogenetic proteins are responsible for layering the proteinaceous layers during spore morphogenesis. Previous studies have analyzed the dependence of certain coat proteins on the well-known morphogenetic proteins such as SpoIVA, CotE, CotH etc. Yet many coat prote...
متن کاملThe timing of cotE expression affects Bacillus subtilis spore coat morphology but not lysozyme resistance.
The synthesis of structural components and morphogenetic factors required for the assembly of the Bacillus subtilis spore coat is governed by a mother cell-specific transcriptional cascade. The first two temporal classes of gene expression, which involve RNA polymerase sigma sigma(E) factor and the ancillary regulators GerR and SpoIIID, are deployed prior to engulfment of the prespore by the mo...
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